Tag Archive for: wesley hospital urologist brisbane

Cxbladder Urine Testing for Urothelial Cancer: Diagnosis, Surveillance, Accuracy and Pitfalls

/0 Comments/in , /by

Bladder cancer surveillance can feel repetitive: another cystoscopy, another urine sample and another anxious wait. This has driven interest in urine-based molecular tests that may help identify patients at very low risk of recurrent urothelial carcinoma.

One such platform is Cxbladder. It is sometimes informally called “Cx View,” but the established commercial name is Cxbladder. The version designed for patients who already have a history of urothelial cancer is Cxbladder Monitor.

Cxbladder can provide useful additional information, particularly when the clinical question is whether cancer is unlikely to be present. However, it is not a stand-alone diagnosis, does not show where a tumour is located and should not automatically replace cystoscopy, imaging or biopsy.

What is the Cxbladder test?

Cxbladder is a non-invasive laboratory test performed on voided urine. It measures the expression of five messenger RNA biomarkers associated with urothelial carcinoma:

  • IGFBP5
  • HOXA13
  • MDK
  • CDK1
  • CXCR2

The result is calculated using a proprietary algorithm. Depending on the particular Cxbladder assay, clinical variables may also be incorporated into risk assessment.

The test looks for a molecular signal shed into urine by urothelial cancer cells. It does not provide a picture of the bladder, determine tumour size or location, reliably assign stage or grade, or replace histopathological examination.

The different Cxbladder tests are not interchangeable

The name “Cxbladder” covers several tests developed for different clinical settings.

Cxbladder Triage

This is designed primarily to help identify patients with haematuria who have a low probability of urothelial cancer. It prioritises sensitivity and negative predictive value, accepting lower specificity.

Cxbladder Detect

This is intended to help identify urothelial cancer in patients undergoing diagnostic evaluation, such as those presenting with haematuria. It is not specifically designed for post-treatment surveillance.

Cxbladder Monitor

This is designed for patients with a previous diagnosis of urothelial carcinoma who are undergoing surveillance for recurrence. It is the most relevant assay for follow-up after treatment of non-muscle-invasive bladder cancer (NMIBC).

Newer or region-specific Cxbladder combinations may use different algorithms and thresholds. Performance figures from one assay should not be transferred uncritically to another.

How is the sample collected?

The patient provides a voided urine sample into the supplied collection system. No catheter is normally required. The sample is stabilised and sent to a specialised laboratory for analysis.

Collection instructions must be followed carefully. Insufficient urine, incorrect handling, contamination, excessive delay or failure to use the correct collection container may produce an invalid or unreliable result. A repeat sample may occasionally be required.

What role can Cxbladder have in initial diagnosis?

For a patient with visible or microscopic haematuria, Cxbladder may help refine the estimated probability of urothelial cancer. A low-risk result can be reassuring, especially in a carefully selected lower-risk patient.

However, haematuria can be caused by bladder cancer, upper-tract urothelial cancer, renal cancer, urinary stones, infection, benign prostate bleeding and other conditions. A urine biomarker cannot evaluate all these causes. Depending on age, symptoms and risk factors, the patient may still require cystoscopy and upper-tract imaging.

Current guideline-based haematuria assessment is risk stratified. Urine markers may support shared decision-making in selected patients, but should not delay investigation of visible haematuria or replace a complete assessment in a patient at significant risk.

How may Cxbladder Monitor be used in surveillance?

After treatment of NMIBC, conventional surveillance may include:

  • cystoscopy;
  • urine cytology in selected intermediate- and high-risk patients;
  • upper-tract imaging when indicated; and
  • biopsy or TURBT when a suspicious lesion is found.

Cxbladder Monitor may be added to this pathway to help identify patients with a low probability of recurrent disease. In selected lower-risk situations, a negative result may support extending the interval to cystoscopy or avoiding an additional cystoscopy, provided this forms part of a urologist-directed protocol.

A positive result does not prove that a recurrence is present. It usually means that further assessment, commonly cystoscopy, and sometimes cytology, enhanced cystoscopy, imaging or biopsy is warranted.

The test should be used particularly cautiously in patients with previous high-grade disease, carcinoma in situ (CIS), recent positive cytology, new haematuria, concerning symptoms or a history suggesting a high risk of progression. Missing high-grade recurrence carries much greater consequences than postponing a procedure in a genuinely low-risk patient.

How accurate is Cxbladder Monitor?

Published validation data have generally shown that Cxbladder Monitor is better at ruling out recurrence than confirming it.

Across key validation studies, reported performance has been approximately:

  • sensitivity: 91–93%;
  • negative predictive value (NPV): 96–97%;
  • specificity: approximately 34–39%; and
  • positive predictive value (PPV): approximately 21% in some validation cohorts.

One comparative study reported sensitivity of 91% and NPV of 96% for Cxbladder Monitor, outperforming cytology, NMP22 and UroVysion FISH for sensitivity in that study population. Another validation reported sensitivity of 93% and NPV of 97%.

These results need careful interpretation.

What does a negative predictive value of 97% mean?

In a study population similar to the one in which that figure was measured, about 97 of every 100 patients with a negative result did not have a detected recurrence, while approximately three could still have disease.

It does not mean the test is “97% accurate” in every patient. NPV changes with the underlying prevalence of recurrence. It will usually look higher in a low-risk population and lower when recurrence is common.

Why is the positive predictive value relatively low?

When specificity is low, many patients with a positive result will not have cancer confirmed on the subsequent assessment. A positive test is therefore a prompt to investigate, not a cancer diagnosis.

Does it detect high-grade disease better?

Urine-based biomarkers often perform better for biologically active high-grade tumours than for very small low-grade recurrences. Nevertheless, no negative urine test can guarantee that high-grade tumour or CIS is absent. Study populations also differ in the proportions of low-grade, high-grade and recently treated patients, making direct comparisons difficult.

Important pitfalls

1. A negative result can be falsely reassuring

False negatives occur. Small, low-volume or intermittently shedding tumours may release too little RNA into the urine. A diluted or poorly collected sample may also reduce the signal. A negative result must not override visible haematuria, positive cytology, a suspicious cystoscopy or a high-risk clinical history.

2. A positive result is not proof of cancer

Because Monitor is deliberately designed to be sensitive, specificity is modest. A positive result may lead to cystoscopy or biopsy that finds no tumour. The test cannot identify the lesion’s location, stage or grade.

3. Infection, inflammation and recent instrumentation complicate interpretation

Urinary infection, stones, bleeding, recent cystoscopy, catheterisation, TURBT, intravesical BCG or chemotherapy can alter urinary cellular material and the clinical context. Cxbladder includes an inflammatory-associated marker intended to reduce this “background noise,” but real-world confounding is not eliminated. Testing should be timed and interpreted by the treating urologist.

4. The test does not examine the upper urinary tract

Urothelial cancer may arise in the ureter or renal pelvis. A urine result cannot localise a tumour or replace CT urography, ureteroscopy or other upper-tract evaluation when clinically indicated.

5. It does not replace pathology

Only tissue examination can determine tumour grade, assess invasion and guide definitive treatment. Cxbladder is a risk-stratification tool rather than a histological diagnosis.

6. Performance may not generalise perfectly

Some studies were supported by or involved investigators connected with the test manufacturer. Many validation cohorts were enriched for particular risk groups and may not reflect every Australian practice. Independent prospective studies, longer follow-up and trials showing that biomarker-guided surveillance preserves oncological outcomes are especially important.

7. “Fewer cystoscopies” is not the same as “no cystoscopies”

Real-world studies suggest that Cxbladder Monitor can reduce cystoscopy frequency in selected low-risk patients. This should not be extrapolated to high-risk NMIBC or used to abandon risk-based surveillance. Cystoscopy remains the direct method of inspecting the bladder and permits immediate biopsy or resection planning.

8. Cost and access vary

Availability, laboratory turnaround time, out-of-pocket cost and reimbursement vary by location and insurer. Australian patients should confirm current access and costs with their urologist and testing provider before collection.

How does it compare with urine cytology?

Urine cytology is highly specific for high-grade urothelial carcinoma but has limited sensitivity, particularly for low-grade tumours. Cxbladder Monitor generally has higher reported sensitivity and NPV, but substantially lower specificity.

The tests therefore answer slightly different questions:

  • cytology: a clearly positive result strongly raises concern for high-grade disease;
  • Cxbladder Monitor: a negative result may help identify a low probability of recurrence; and
  • cystoscopy: directly visualises the bladder and remains central to surveillance.

Combining information may be more useful than treating any one result in isolation.

What do international guidelines say?

Major guidelines acknowledge that urinary molecular markers are improving, but remain cautious about their routine use as complete substitutes for cystoscopy.

  • The AUA/SUO NMIBC guideline states that urinary biomarkers should not replace cystoscopic evaluation during surveillance. Markers may be used in selected settings, including assessment of an equivocal cytology result or response to intravesical BCG.
  • The EAU NMIBC guideline recognises that molecular urine tests may have a future role in reducing cystoscopy frequency, particularly in lower-risk surveillance, but notes that evidence and prospective implementation data remain insufficient for a universal marker-driven schedule.
  • Guideline recommendations evolve as new trials emerge; decisions should be based on the patient’s individual recurrence and progression risk rather than the availability of a test alone.

A practical, balanced approach

Cxbladder Monitor is most helpful when the question is: “Is recurrence sufficiently unlikely that we can safely reduce or postpone an invasive investigation in this particular patient?”

It is less useful as a stand-alone answer to: “Does this patient definitely have cancer, where is it, and how aggressive is it?”

For a carefully selected patient with previous low-risk NMIBC, no new symptoms and a negative Monitor result, a biomarker-informed surveillance plan may reduce unnecessary cystoscopies. For a patient with previous CIS or high-grade tumour, positive cytology, visible haematuria or a suspicious finding, conventional investigation should not be deferred because of a negative urine test.

The result is best interpreted alongside tumour history, grade and stage, time since treatment, cystoscopy findings, cytology, imaging and the patient’s preferences.

References

  1. Kavalieris L, O’Sullivan P, Frampton C, et al. Performance characteristics of a multigene urine biomarker test for monitoring for recurrent urothelial carcinoma in a multicenter study. J Urol. 2017;197(6):1419–1426. PubMed search
  2. Lotan Y, O’Sullivan P, Raman JD, et al. Clinical comparison of noninvasive urine tests for ruling out recurrent urothelial carcinoma. Urol Oncol. 2017;35(8):531.e15–531.e22. PubMed search
  3. O’Sullivan P, Sharples K, Dalphin M, et al. A multigene urine test for the detection and stratification of bladder cancer in patients presenting with hematuria. J Urol. 2012;188(3):741–747. PubMed search
  4. Li KD, McLennan MT, Barocas DA, et al. Cxbladder Monitor testing to reduce cystoscopy frequency in patients with bladder cancer. J Urol. 2023. PubMed
  5. Konety B, Shore N, Kader AK, et al. Evaluation of Cxbladder and adjudication of atypical cytology and equivocal cystoscopy. Eur Urol. 2019;76(2):238–243. PubMed search
  6. Darling D, Luxmanan C, O’Sullivan P, et al. Clinical utility of Cxbladder for the diagnosis of urothelial carcinoma. Adv Ther. 2017;34:1087–1096. PubMed search
  7. Breen V, Kasabov N, Kamat AM, et al. A holistic comparative analysis of diagnostic tests for urothelial carcinoma: a study of Cxbladder Detect, UroVysion FISH, NMP22 and cytology. BMC Med Res Methodol. 2015;15:27. Full text
  8. Harvey JC, et al. Analytical validation of Cxbladder Detect, Triage, and Monitor assays for detection and management of urothelial carcinoma. Diagnostics. 2024;14(18):2061. Full text
  9. Holzbeierlein JM, Bixler BR, Buckley DI, et al. Diagnosis and treatment of non-muscle invasive bladder cancer: AUA/SUO guideline. American Urological Association; amended 2024. AUA guideline
  10. European Association of Urology. EAU Guidelines on Non-Muscle-Invasive Bladder Cancer. Current online edition. EAU guideline
  11. Barocas DA, Lotan Y, Matulewicz RS, et al. Updates to microhematuria: AUA/SUFU guideline. J Urol. 2025. PubMed

This article provides general information and does not replace personalised medical advice. Surveillance should be tailored to the original tumour’s stage and grade, prior treatment, current symptoms and the individual’s risk of recurrence and progression.

The Story Behind The “Happy Prostate”

/0 Comments/in /by

More than a logo

The Happy Prostate is not simply a practice logo. It began as an original artwork that I painted myself, and it now hangs in my study at home.

Its cheerful expression reflects what I hope to achieve when caring for men with prostate and urinary problems: less worry, better understanding, improved bladder function and renewed confidence.

The prostate may be a small gland, but when it misbehaves, it can have an enormous effect on daily life. It can interrupt sleep, dictate travel plans, interfere with intimacy and leave a man constantly searching for the nearest toilet.

The Happy Prostate represents the other side of that story the moment when a man feels that he has regained control of his life. Having had prostate surgery myself, I am on the same page as my patients, I get you. And no, I did not do it myself!

When a growing prostate becomes a grumpy prostate

Benign prostatic hyperplasia, or BPH, is the non-cancerous enlargement of the prostate that commonly develops as men age.

An enlarged prostate may compress the urinary passage and cause:

  • A slow or interrupted urinary stream
  • Difficulty starting urination
  • Straining to pass urine
  • A feeling that the bladder has not emptied
  • Urgency and frequent urination
  • Getting up repeatedly during the night
  • Urinary retention or recurrent infections

Not every enlarged prostate needs surgery. Treatment begins with understanding the symptoms, examining the prostate and assessing bladder emptying, urinary flow, PSA and other relevant factors.

When a procedure is needed, there is no single operation that suits every man. Modern BPH treatment can be tailored according to prostate size and shape, symptom severity, bladder function, general health and the importance of preserving ejaculation.

Steam

Water-vapour therapy delivers small amounts of controlled steam into selected areas of enlarged prostate tissue. The treated tissue gradually shrinks, creating more room for urine to pass.

It may suit selected men looking for a minimally invasive option with a relatively low risk of sexual side effects. Improvement develops gradually rather than overnight.

Clips or a prostatic urethral lift

Tiny implants can be used to hold enlarged prostate tissue away from the urinary channel. Nothing is cut away.

This approach may offer a rapid recovery and a good chance of preserving ejaculation in appropriately selected men. Prostate anatomy is important, and some men may require further treatment later.

Temporary prostate stents or implants

A temporary implant can reshape the prostatic urethra without leaving a permanent device behind. It is usually removed after several days.

This can be useful for carefully selected prostates, although symptom improvement and long-term durability may not equal those achieved with more definitive tissue-removing procedures.

Laser treatment

Laser surgery can vaporise or enucleate obstructing prostate tissue. The technique selected depends on prostate size, anatomy, bleeding risk and the available equipment and expertise.

Laser treatment can provide powerful relief of obstruction, but temporary urgency, burning, bleeding and changes in ejaculation may occur during recovery.

Bipolar energy

Bipolar electrical energy can remove or enucleate enlarged prostate tissue while controlling bleeding. Bipolar TURP remains an established surgical option for many men with bothersome urinary obstruction.

Robotic-assisted enucleation

Very large prostates may be treated by robotic-assisted simple prostatectomy or enucleation. The obstructing inner portion of the prostate is removed while the outer capsule remains.

This is a more substantial procedure than a minimally invasive treatment, but it can provide excellent relief when a very large prostate is causing severe obstruction, retention, infections, bladder stones or kidney problems.

The right procedure is not necessarily the newest or the biggest. It is the procedure that best matches the individual man and his priorities. Current guidelines emphasise shared decision-making because treatments differ in effectiveness, recovery, durability and effects on sexual function. (EAU Male LUTS guideline)

When the diagnosis is prostate cancer

The words “prostate cancer” naturally produce fear, but prostate cancer is not one uniform disease. Some cancers grow so slowly that immediate treatment may cause more harm than benefit. Others require timely and decisive treatment.

The goal is to understand the cancer accurately and choose a strategy that balances cancer control with urinary, sexual and general health.

Active surveillance

For appropriately selected men with low-risk—and some favourable intermediate-risk—prostate cancer, active surveillance can avoid or delay unnecessary treatment.

It does not mean ignoring the cancer. It is a structured programme that may include:

  • Regular PSA testing
  • Clinical review
  • Prostate MRI
  • Repeat biopsy when indicated
  • Conversion to active treatment if there are signs of progression

The aim is to preserve quality of life while retaining the opportunity for curative treatment if the cancer changes. (EAU Prostate Cancer guideline)

Robotic-assisted radical prostatectomy

Robotic-assisted radical prostatectomy removes the prostate and seminal vesicles with the intention of curing localised prostate cancer.

Where it is oncologically safe, nerve-sparing and careful reconstruction may help preserve erectile function and accelerate recovery of urinary control. Cancer clearance remains the first priority, and continence and sexual outcomes vary between men.

Focal therapy

Focal therapy treats the cancerous area while attempting to preserve as much normal prostate tissue as possible. Techniques may include irreversible electroporation, focal laser ablation, high-intensity focused ultrasound or cryotherapy.

It may be considered for carefully selected men with localised, MRI-visible disease who understand the need for close follow-up. Focal therapy is not suitable for every prostate cancer, and long-term comparative evidence continues to develop. Some international guidelines recommend that it be performed within structured prospective studies or registries.

When continence is preserved, improved or restored

Urinary continence is one of the most important themes represented by the Happy Prostate.

Whenever possible, treatment planning aims to preserve continence. This involves careful patient selection, thoughtful surgical technique, protection of the urinary sphincter and appropriate pelvic-floor preparation and rehabilitation.

When leakage occurs, it should never be dismissed as something a man must simply tolerate. Assessment may include a bladder diary, pad testing, urine-flow measurement, ultrasound, cystoscopy or urodynamic studies. This helps distinguish weakness of the urinary sphincter from urgency, overactive bladder, obstruction or poor bladder emptying.

Depending on the cause, continence may be improved or restored through:

  • Pelvic-floor rehabilitation
  • Bladder training and lifestyle measures
  • Medication for urgency or overactive bladder
  • Treatment of residual obstruction
  • A male urethral sling
  • An artificial urinary sphincter
  • Other carefully selected continence procedures

The joyful progression shown in the Happy Prostate GIF represents this recovery: uncertainty giving way to hope, improvement and confidence. As urinary control returns, the character stands taller, moves with greater freedom and finally throws away his diaper.

The humour is intentional, but so is the dignity behind it. Incontinence can affect work, exercise, travel, intimacy and self-esteem. Restoring continence is not merely about keeping underwear dry, it is about helping a man feel comfortable in the world again.

As I like to put it:

When treatment works, the bladder stops writing the day’s itinerary and the diaper can take the day off.

A small painting with a larger purpose

The original Happy Prostate painting hanging in my home study reminds me that urology is not only about scans, PSA results, flow rates and surgical technology. It is about the man sitting on the other side of the desk.

A prostate becomes truly “happy” when its owner:

  • Understands what is happening
  • Feels comfortable discussing embarrassing symptoms
  • Has treatment suited to his individual circumstances
  • Maintains or regains urinary control
  • Can return to sleep, exercise, travel and intimacy with confidence
  • Feels that he has been heard and treated with dignity

A little humour can open the door, but dignity keeps the conversation going.

That is the story of the Happy Prostate: an original painting, a slightly cheeky character and a serious commitment to helping men regain comfort, confidence and joy.

Dr Jo Schoeman
The “Happy-Prostate” Urologist

This article provides general information and does not replace an individual medical assessment. The suitability, benefits and potential complications of each treatment should be discussed with a urologist.

Balanitis Xerotica Obliterans and Lichen Sclerosus of the Foreskin

/0 Comments/in , /by

Balanitis xerotica obliterans—usually abbreviated to BXO, is the traditional urological name for male genital lichen sclerosus.

Lichen sclerosus is a chronic inflammatory skin condition that most commonly affects the foreskin and head of the penis. It can cause whitening, inflammation, splitting and progressive scarring of the foreskin. In some men it also narrows the urinary opening or extends into the urethra.

BXO is not simply an infection or ordinary balanitis. Early recognition and treatment can relieve symptoms and reduce permanent scarring. Long-term observation is also important because genital lichen sclerosus is associated with a small but genuine risk of penile squamous cell carcinoma.

Is BXO different from lichen sclerosus?

The names are often used interchangeably:

  • Lichen sclerosus is the preferred modern medical term.
  • Balanitis xerotica obliterans describes lichen sclerosus affecting the glans penis and foreskin, particularly when scarring has developed.

The condition may involve:

  • The inner and outer foreskin
  • The glans penis
  • The frenulum
  • The urinary opening—the meatus
  • The fossa navicularis and penile urethra

The disease is usually confined to the genital region in men, although lichen sclerosus can occasionally affect skin elsewhere.

What causes lichen sclerosus?

The exact cause remains uncertain. It is probably produced by a combination of inflammation, immune-system dysfunction, genetic susceptibility, skin injury and local environmental factors.

Possible associations include:

  • Autoimmune or inflammatory activity
  • Chronic exposure of susceptible skin to trapped urine
  • Repeated friction or minor trauma
  • A tight foreskin
  • Previous inflammation beneath the foreskin
  • Obesity and a “buried” penis
  • Diabetes or metabolic disease
  • Cigarette smoking
  • Genetic susceptibility

The moist, occluded environment beneath the foreskin may contribute to continuing inflammation in susceptible men.

Lichen sclerosus is:

  • Not caused by poor personal character or behaviour
  • Not usually a sexually transmitted infection
  • Not contagious
  • Not something that can be passed to a partner through ordinary sexual contact

Yeast or bacterial infection may occur at the same time, particularly in men with diabetes, but infection is not the underlying cause of lichen sclerosus.

Who can develop it?

Male genital lichen sclerosus can occur at any age.

It is recognised in:

  • Boys with acquired or severe scarring phimosis
  • Adolescents
  • Younger and middle-aged men
  • Older men
  • Men with a previously retractable foreskin that has gradually tightened

It is much less common in men who were circumcised early in life, although circumcision does not make the risk absolutely zero.

How does lichen sclerosus present?

The appearance varies considerably. Early disease can be subtle and may initially be mistaken for thrush, dermatitis, recurrent balanitis or ordinary phimosis.

Possible signs include:

  • White, pale or porcelain-coloured foreskin
  • A white, firm ring around the foreskin opening
  • Thickened or hardened skin
  • Shiny, crinkled or “cigarette-paper” skin
  • Red or inflamed areas
  • Small cracks or splits
  • Easy bleeding or bruising
  • Painful erosions
  • Adhesions between the foreskin and glans
  • Progressive tightening of the foreskin
  • Shortening or scarring of the frenulum
  • Whitening around the urinary opening
  • Narrowing of the meatus
  • Loss of the normal shape or definition of the glans and foreskin

Some men have significant visible disease with surprisingly little discomfort.

Symptoms patients may notice

Symptoms can include:

  • Difficulty retracting the foreskin
  • Inability to replace or retract the foreskin fully
  • Pain during erections
  • Splitting or bleeding during intercourse
  • Itching, burning or soreness
  • Recurrent “balanitis”
  • Pain or reduced enjoyment during sexual activity
  • Spraying or deflection of the urinary stream
  • A weak or narrowed stream
  • Straining to urinate
  • Dribbling after urination
  • Ballooning of the foreskin
  • Recurrent urinary infections
  • Difficulty emptying the bladder

A narrow urinary opening may be the first sign that the disease has extended beyond the foreskin.

Lichen sclerosus and phimosis

Phimosis means that the foreskin cannot be retracted comfortably behind the glans.

A non-retractile foreskin is normal in young boys and does not automatically indicate disease. However, a previously retractable foreskin that becomes tight, particularly when accompanied by a white scarred ring is suspicious for lichen sclerosus.

Forceful stretching of a scarred foreskin is not recommended. Repeated tearing may cause additional inflammation and scarring.

Paraphimosis, where a retracted tight foreskin becomes trapped behind the glans, requires urgent medical attention.

How is lichen sclerosus diagnosed?

The diagnosis is often made from the history and characteristic appearance.

Assessment should include examination of:

  • The complete foreskin
  • Glans penis
  • Frenulum
  • Urinary opening
  • Palpable tissue beneath abnormal skin
  • Urinary stream and bladder emptying when relevant
  • Groin lymph nodes if cancer is suspected

Other conditions that can resemble lichen sclerosus include:

  • Fungal or bacterial balanitis
  • Irritant or allergic dermatitis
  • Psoriasis
  • Lichen planus
  • Zoon balanitis
  • Vitiligo
  • Genital warts
  • Penile intraepithelial neoplasia: PeIN
  • Squamous cell carcinoma

Diabetes testing may be appropriate in men with recurrent inflammation or other risk factors.

Is a biopsy always necessary?

Not every typical case requires a biopsy before treatment. However, biopsy is important when:

  • The diagnosis is uncertain
  • Treatment has not produced the expected response
  • An erosion or ulcer does not heal
  • There is a persistent red or thickened area
  • A lump or hardened area can be felt
  • The skin bleeds easily without an obvious cause
  • Pigmentation changes unexpectedly
  • Penile intraepithelial neoplasia or cancer is suspected

When circumcision is performed for suspected lichen sclerosus, the foreskin should usually be sent for pathological examination.

A biopsy should be taken from any suspicious persistent lesion rather than relying only on the appearance.

Medical management

The goals of medical treatment are to:

  • Suppress inflammation
  • Relieve discomfort and itching
  • Prevent further scarring
  • Preserve foreskin and urinary function where possible
  • Identify patients who require surgery or biopsy

General skin care

Helpful measures include:

  • Washing gently with water or a non-soap cleanser
  • Avoiding perfumed soaps, antiseptics and harsh products
  • Drying the glans and foreskin gently after urination
  • Applying a bland barrier ointment or emollient
  • Avoiding forceful foreskin retraction
  • Using adequate lubrication during sexual activity
  • Stopping smoking
  • Managing diabetes carefully
  • Addressing obesity or a buried penis where relevant

Good hygiene means gentle care. Repeated scrubbing or strong antiseptics can worsen inflamed genital skin.

Potent topical corticosteroids

A prescribed potent or ultrapotent topical corticosteroid is the usual first-line medical treatment.

Clobetasol propionate 0.05% ointment is commonly used in specialist practice. A typical initial course may involve a small amount applied to the affected skin once daily for one to three months, but the exact regimen should be determined by the treating doctor.

Patients should be shown:

  • Exactly where to apply the medication
  • How much to use
  • How long to continue
  • Whether treatment should be reduced gradually
  • When follow-up is required

When used correctly for a defined course, topical corticosteroids can reduce inflammation, soreness and early tightening. They cannot always reverse established dense scar tissue.

Possible steroid-related effects include irritation, secondary infection, skin thinning or visible small blood vessels, although these are uncommon with appropriate genital use and medical supervision.

Other topical treatments

Topical calcineurin inhibitors such as tacrolimus or pimecrolimus may occasionally be considered by a dermatologist or experienced specialist when corticosteroids are unsuitable.

They are not generally preferred over potent topical corticosteroids as initial treatment. They can cause burning or irritation, and persistent suspicious lesions must be biopsied rather than repeatedly treated empirically.

Antifungal or antibiotic medication is only useful when a secondary infection is actually present. It does not treat the underlying lichen sclerosus.

When should circumcision be considered?

Circumcision is an important and often definitive treatment for foreskin lichen sclerosus.

It should be considered when there is:

  • Established scarring phimosis
  • Painful or recurrent splitting
  • Difficulty with hygiene
  • Recurrent balanitis
  • Paraphimosis
  • Failure to respond adequately to a prescribed steroid course
  • Rapid recurrence after apparently successful medical treatment
  • Significant functional or sexual difficulty
  • Concern about premalignant or malignant change
  • A need to obtain tissue for diagnosis

Complete circumcision removes the diseased foreskin and eliminates the moist, urine-exposed environment beneath it. Many men experience long-term resolution when the disease is limited to the foreskin.

Partial circumcision or simply making a slit in the scarred foreskin is generally less reliable because affected skin remains and may scar again.

Will circumcision cure lichen sclerosus?

Circumcision is often highly effective when the condition is limited to the foreskin. However, it is not an absolute guarantee of cure.

Disease may persist or recur on the:

  • Glans
  • Coronal sulcus
  • Frenulum
  • Urinary opening
  • Urethra

Ongoing symptoms or abnormal skin after circumcision should therefore be reviewed rather than assumed to be normal postoperative scarring.

Circumcision appears to reduce the risk associated with chronic inflammation and phimosis, but it does not completely eliminate the future risk of penile cancer.

Surgery for meatal narrowing

Lichen sclerosus can scar the urinary opening, producing meatal stenosis.

Symptoms may include:

  • A thin urinary stream
  • Spraying or deflection
  • Prolonged urination
  • Straining
  • Discomfort
  • Incomplete emptying

Treatment may require a meatotomy or meatoplasty, in which the opening is enlarged and reconstructed.

Simple dilatation may provide temporary improvement but often does not control active scar disease. Medical treatment of the surrounding lichen sclerosus and continued surveillance may still be required.

What if the disease involves the urethra?

In some men, scarring extends from the meatus into the penile urethra and occasionally further towards the bulbar urethra.

Assessment may include:

  • Urinary flow-rate testing
  • Post-void residual ultrasound
  • Flexible cystoscopy
  • Retrograde urethrogram
  • Voiding cystourethrogram
  • Urethral ultrasound in selected cases

Short strictures may sometimes be managed endoscopically, but repeated dilatation or urethrotomy has a significant recurrence risk when active lichen sclerosus remains.

Longer or recurrent strictures may require urethroplasty. Oral lining tissue, usually buccal mucosa from the inside of the cheek, is commonly used for reconstruction.

The European Association of Urology recommends that genital skin should not be used as a graft for lichen-sclerosus-related urethral strictures, because the disease can affect the graft and recurrence rates are poor.

Complex cases are best managed by a urologist experienced in reconstructive urethral surgery.

Other surgical options

Depending on the extent of disease, specialist procedures may include:

  • Frenuloplasty in carefully selected cases without extensive LS
  • Complete circumcision
  • Meatotomy or meatoplasty
  • Excision or biopsy of suspicious lesions
  • Glans resurfacing when premalignant disease is present
  • Oral-mucosa graft urethroplasty
  • Staged urethral reconstruction
  • Perineal urethrostomy for severe or recurrent extensive stricture disease

The operation should be tailored to the location and activity of the condition. Preserving diseased genital skin simply to avoid circumcision may produce repeated scarring and further procedures.

Lichen sclerosus and penile cancer

Male genital lichen sclerosus is associated with squamous cell carcinoma of the penis and with penile intraepithelial neoplasia, which is a precancerous change.

Published studies have reported widely differing cancer rates among men with genital lichen sclerosus, from close to zero in some groups to approximately 12.5% in highly selected specialist series. Frequently quoted estimates place the risk at roughly 2–6%, but the precise lifetime risk for an individual man remains uncertain.

This does not mean that most men with lichen sclerosus will develop penile cancer. Penile cancer remains rare, and appropriate treatment of inflammation and phimosis is expected to reduce risk.

It is also reported that lichen sclerosus is found in a substantial proportion of penile cancer specimens. This association cannot be reversed to mean that the same proportion of men with lichen sclerosus will develop cancer.

Risk is likely to be greater when there is:

  • Long-standing uncontrolled inflammation
  • Severe phimosis
  • Persistent ulceration or thickening
  • Poor visibility of the glans
  • Cigarette smoking
  • Immune suppression
  • Coexisting penile intraepithelial neoplasia
  • Failure to attend follow-up

Warning signs that require prompt review

A man with current or previous lichen sclerosus should seek medical assessment for:

  • A persistent ulcer or sore
  • A new lump or firm area
  • Skin thickening
  • An irregular red or velvety patch
  • A warty or cauliflower-like growth
  • Unexplained bleeding
  • Offensive discharge
  • Increasing pain
  • A lesion that does not respond to prescribed steroid treatment
  • A new lump in the groin

These findings do not necessarily mean cancer, but they should not be treated repeatedly as thrush or simple inflammation without further investigation.

Follow-up and self-examination

Lichen sclerosus can recur, and cancer-related changes may develop many years after initial treatment.

Patients should become familiar with the normal appearance of their penis and perform regular self-examination. When possible, the entire glans, foreskin and urinary opening should be inspected.

Medical follow-up should be tailored to disease severity. More frequent review is appropriate during active treatment, after surgery or when urethral involvement is present. Once stable, periodic or annual review may be appropriate, together with lifelong self-monitoring.

Circumcised men should still report new or persistent abnormalities.

The outlook

When recognised early, male genital lichen sclerosus can often be controlled successfully with appropriate topical corticosteroid treatment, good skin care and follow-up.

Established scarring is less likely to resolve with medication alone. Circumcision is usually highly effective for disease confined to the foreskin, while meatal and urethral disease may require more specialised reconstruction.

The important message is not to ignore a foreskin that is becoming progressively white, scarred or tight. Early assessment may prevent painful erections, urinary obstruction and more complex surgery.

The bottom line

Balanitis xerotica obliterans is the older name for male genital lichen sclerosus involving the foreskin and glans.

It commonly presents with white or scarred skin, acquired phimosis, splitting, painful erections or urinary-stream changes. Potent prescribed topical corticosteroids are the first medical treatment for suitable early disease, while circumcision is often required for established phimosis, recurrent disease or failure of medical treatment.

Meatal or urethral involvement requires urological assessment and may need reconstructive surgery.

The risk of penile squamous cell carcinoma is small but real. Persistent thickening, ulceration, bleeding, a lump or a lesion that does not respond to treatment requires prompt examination and often biopsy.

This article provides general information and does not replace personalised medical assessment. Do not use potent topical corticosteroids on genital skin without appropriate medical advice.

So guys, if you cannot retract the foreskin and has the typical appearance discussed in this article, take the time to review with your GP to have this checked out. There is effective management for this which will also then reduce your risk for penile cancer. Do not vary your head in the send and ignore this, have it seen to and let your GP refer you to your local Brisbane urologist, Dr Jo Schoeman.

References and further reading

Duodart® for an Enlarged Prostate: Benefits, Side Effects and When Surgery May Be Better

/0 Comments/in , /by

Benign prostatic hyperplasia, usually called BPH or benign prostate enlargement, is a common cause of urinary symptoms as men get older.

An enlarged prostate can compress the urethra and interfere with bladder emptying, causing symptoms such as:

  • A slow or intermittent urinary stream
  • Difficulty starting urination
  • Straining to urinate
  • A feeling that the bladder has not emptied
  • Urinary frequency or urgency
  • Waking repeatedly at night to urinate
  • Dribbling after urination
  • Episodes of urinary retention

Duodart® combines two established BPH medicines in a single daily capsule. One component relaxes the prostate relatively quickly, while the other gradually reduces its size and lowers the long-term risk of urinary retention and prostate surgery.

Duodart can be very effective in appropriately selected men, but it is not the right treatment for every urinary symptom or every prostate.

What does Dutasteride contain?

Each Duodart capsule contains:

  • Dutasteride 0.5 mg
  • Tamsulosin hydrochloride 0.4 mg

These medicines work in different but complementary ways.

Tamsulosin: relaxing the prostate

Tamsulosin is an alpha-1 adrenergic receptor blocker. It relaxes smooth muscle within the prostate and bladder neck, reducing resistance to urinary flow.

It may improve:

  • Urinary stream
  • Hesitancy
  • Straining
  • Bladder emptying
  • Some frequency and urgency symptoms

Improvement may begin within days, although the full response can take several weeks.

Tamsulosin improves urinary symptoms but does not substantially reduce prostate size or prevent long-term prostate growth.

Dutasteride: gradually shrinking the prostate

Dutasteride is a 5-alpha-reductase inhibitor, 5-ARI. It blocks both type 1 and type 2 forms of the enzyme that converts testosterone into dihydrotestosterone (DHT).

DHT is an important driver of prostate growth. Reducing DHT gradually causes susceptible prostate tissue to shrink.

According to the European Association of Urology, 5-ARIs can:

  • Reduce prostate volume by approximately 18–28%
  • Improve urinary symptom scores by approximately 15–30%
  • Reduce PSA by approximately 50% after six to twelve months
  • Reduce the long-term risk of acute urinary retention
  • Reduce the likelihood of requiring BPH surgery

The dutasteride component works slowly. A meaningful benefit may take three to six months, with further improvement occurring over several years.

Who may benefit from Duodart?

Duodart is most appropriate for men with moderate-to-severe urinary symptoms caused by an enlarged prostate who also have an increased risk of BPH progression.

It may be considered when there is:

  • A prostate volume of approximately 40 mL or greater
  • A clearly enlarged prostate on examination or ultrasound
  • An elevated PSA consistent with benign prostate enlargement
  • A reduced urinary flow rate
  • An increased post-void residual urine volume
  • Increasing symptoms despite alpha-blocker treatment
  • A risk of future urinary retention
  • A desire to reduce the likelihood of BPH-related surgery
  • A need for both relatively rapid symptom relief and long-term reduction in prostate size

Some men with prostates between 30 and 40 mL may also benefit, depending on their PSA, symptoms, urinary flow and other risk factors.

Combination treatment is generally intended for long-term use rather than a short trial lasting only a few weeks.

Who may not benefit?

Duodart is less likely to help when:

  • The prostate is small
  • Symptoms are primarily caused by an overactive bladder
  • There is poor bladder-muscle contraction
  • A urethral stricture is present
  • Prostate or bladder cancer is causing the obstruction
  • A bladder stone is responsible for the symptoms
  • Neurological bladder dysfunction is present
  • Symptoms are mild and not troublesome

A large prostate and severe symptoms do not always occur together. Some men with a very large prostate urinate reasonably well, while others with a small prostate have significant obstruction from a tight bladder neck, urethral narrowing or abnormal prostate shape.

This is why treatment should be based on an assessment rather than prostate size alone.

What assessment is recommended before starting Duodart?

Depending on the patient, assessment may include:

  • A detailed urinary and medication history
  • International Prostate Symptom Score (IPSS)
  • Physical examination
  • Digital rectal examination
  • Urine testing
  • PSA testing
  • Kidney-function blood tests
  • Urinary flow-rate measurement
  • Ultrasound measurement of prostate size
  • Post-void residual urine measurement
  • A bladder diary when frequency or nocturia is prominent
  • Cystoscopy or urodynamic testing in selected patients

Prostate cancer and other important causes of urinary obstruction should be considered before symptoms are attributed to BPH.

How is Duodart taken?

The usual dose is one capsule once daily, taken approximately 30 minutes after the same meal each day.

The capsule should be swallowed whole. It should not be opened, crushed or chewed because its contents may irritate the mouth and throat.

Taking the capsule consistently after the same meal helps maintain predictable absorption of tamsulosin.

If treatment is stopped, urinary symptoms and prostate growth may gradually return. Duodart should not be stopped or restarted without discussing this with the prescribing doctor.

What benefits can be expected?

Tamsulosin provides the earlier benefit by relaxing the prostate and bladder neck. Dutasteride provides the slower, longer-term benefit by reducing prostate volume and the risk of progression.

In long-term clinical studies, dutasteride plus tamsulosin produced greater improvement in urinary symptoms and urinary flow than either medicine alone in appropriately selected men.

The EAU reports that, compared with tamsulosin alone at four years, combination treatment reduced the relative risk of:

  • Acute urinary retention by approximately 68%
  • BPH-related surgery by approximately 71%
  • Symptom deterioration by approximately 41%

These are relative reductions from clinical-trial populations. The individual absolute benefit depends on the patient’s original risk, prostate size, PSA and degree of obstruction.

Duodart controls BPH; it does not permanently cure it.

Common side effects

Because Duodart contains two medicines, it can cause side effects associated with either component.

Ejaculatory changes

Tamsulosin can interfere with ejaculation. Patients may notice:

  • Reduced semen volume
  • Dry ejaculation
  • Failure to ejaculate
  • Semen passing backwards into the bladder: retrograde ejaculation

This is usually harmless but can affect sexual satisfaction and fertility.

Combination treatment has a higher risk of ejaculatory dysfunction than either an alpha blocker or 5-ARI used alone.

Reduced sexual desire

Dutasteride reduces DHT and may cause a decrease in libido. The effect may be mild for some men but troubling for others.

Erectile dysfunction

Difficulty achieving or maintaining an erection can occur. BPH itself, increasing age, vascular disease, diabetes and other medications can also contribute, so the cause is not always straightforward.

Breast changes

Dutasteride can occasionally cause:

  • Breast tenderness
  • Nipple sensitivity
  • Breast enlargement: gynaecomastia

A breast lump, nipple discharge or persistent one-sided change should be assessed promptly rather than assumed to be a medication effect.

Dizziness and low blood pressure

Tamsulosin may lower blood pressure, particularly when standing. This can cause:

  • Dizziness
  • Light-headedness
  • Weakness
  • Fainting
  • An increased risk of falling

Extra care is needed when treatment begins, after a dose change or when Duodart is combined with other blood-pressure-lowering medicines.

Other possible side effects

Other reported effects include:

  • Headache
  • Tiredness
  • Palpitations
  • Nasal congestion
  • Gastrointestinal discomfort
  • Skin rash or itching
  • Testicular discomfort or swelling
  • Mood changes or depression
  • Reduced fertility or changes in semen quality

Semen-volume and sperm changes do not necessarily cause infertility, but men planning a pregnancy should discuss this before treatment.

Rare but important reactions

Urgent medical assistance is required for:

  • Swelling of the face, tongue or throat
  • Difficulty breathing
  • A severe allergic reaction
  • Fainting
  • A painful erection lasting several hours: priapism
  • Severe blistering or peeling skin
  • Marked depression or suicidal thoughts

These reactions are uncommon but require prompt assessment.

Duodart and cataract surgery

Tamsulosin is associated with intraoperative floppy iris syndrome, which can make cataract or glaucoma surgery more difficult.

Patients should tell their ophthalmologist if they:

  • Currently take Duodart
  • Previously took Duodart
  • Previously used another medicine containing tamsulosin

Stopping tamsulosin shortly before surgery may not completely remove this risk. The decision should be made between the ophthalmologist and prescribing doctor rather than by the patient alone.

Contraindications and important precautions

Duodart should not be used in:

  • Women
  • Children or adolescents
  • Anyone allergic to dutasteride, tamsulosin, another 5-ARI or a capsule ingredient
  • Patients with a history of significant postural or orthostatic hypotension
  • Patients with severe liver impairment

Additional caution is required in men with:

  • Recurrent dizziness or falls
  • Significant cardiovascular disease
  • Liver disease
  • Severe kidney impairment
  • Planned cataract or glaucoma surgery
  • A history of depression or major mood disturbance
  • Suspected prostate cancer
  • Severe urinary retention
  • A very high post-void residual urine volume
  • Other medicines that substantially lower blood pressure

Duodart changes the interpretation of PSA

Dutasteride generally lowers PSA by approximately 50% after six to twelve months.

This does not mean that prostate cancer risk has disappeared. A new PSA baseline should be established after treatment begins, and subsequent results must be interpreted in the context of dutasteride use.

A confirmed rise from the lowest PSA reached while taking Duodart may require investigation, even when the result remains within the laboratory’s usual “normal” range.

Patients should tell any doctor ordering or interpreting a PSA test that they are taking dutasteride.

PSA monitoring and appropriate prostate cancer assessment should continue while using Duodart.

What is “post-finasteride syndrome”?

“Post-finasteride syndrome” is a term used to describe persistent symptoms reported by some patients during or after stopping finasteride.

Reported symptoms have included:

  • Reduced libido
  • Erectile dysfunction
  • Altered genital sensation
  • Ejaculatory or orgasmic changes
  • Fatigue
  • Poor concentration or “brain fog”
  • Anxiety
  • Depressed mood
  • Sleep disturbance

The existence, frequency, biological mechanism and diagnostic criteria of post-finasteride syndrome remain debated. Some patients report very real and persistent symptoms, but current research has not established a reliable way to predict who may be affected or to prove that every reported symptom is directly caused by the medicine.

It should therefore neither be presented as a guaranteed consequence nor dismissed when a patient reports persistent symptoms.

Is post-finasteride syndrome relevant to Duodart?

Duodart does not contain finasteride. It contains dutasteride.

However, finasteride and dutasteride belong to the same 5-ARI medicine class and both reduce DHT. Sexual side effects such as reduced libido, erectile dysfunction and ejaculatory changes are recognised with both medicines.

Dutasteride inhibits both type 1 and type 2 5-alpha-reductase and remains in the body much longer than finasteride. Its terminal half-life is approximately five weeks, so adverse effects may not disappear immediately after stopping treatment.

Persistent sexual symptoms have been reported after treatment with 5-ARIs, although the frequency and causal relationship remain uncertain.

A 2025 European Medicines Agency safety review found insufficient evidence to establish a causal association between dutasteride and suicidal thoughts. Nevertheless, because of a possible class effect, the EMA recommended precautionary information about mood changes for dutasteride products.

Patients taking Duodart should contact their doctor if they develop:

  • New or worsening sexual dysfunction
  • Persistent loss of libido
  • Depressed mood
  • Significant anxiety
  • Suicidal thoughts
  • Symptoms that continue after stopping treatment

Stopping Duodart suddenly may allow urinary obstruction to worsen, so medication changes should usually be supervised. Suicidal thoughts or severe psychological distress require urgent assistance.

Monitoring treatment

Patients should usually be reviewed after starting Duodart to assess:

  • Improvement in urinary symptoms
  • Dizziness or postural blood-pressure changes
  • Sexual and ejaculatory function
  • Mood changes
  • Urinary flow rate
  • Post-void residual urine
  • PSA response
  • Kidney function when clinically indicated

The tamsulosin component should produce an earlier response, while the dutasteride benefit is judged over several months.

A lack of rapid improvement does not necessarily mean dutasteride has failed. Conversely, ongoing severe symptoms should not automatically be managed by continuing the medication indefinitely without reassessment.

When should surgery be considered?

Medication is often the first treatment for uncomplicated BPH, but surgery should not be regarded merely as a last resort. For some patients it offers more reliable relief and prevents further bladder or kidney damage.

Surgery should be considered when there is:

  • Recurrent or persistent urinary retention
  • Dependence on a urinary catheter
  • Recurrent urinary tract infections caused by poor emptying
  • Bladder stones
  • Recurrent visible bleeding attributable to BPH
  • Overflow urinary incontinence
  • Progressive bladder diverticula associated with obstruction
  • Dilatation of the kidneys or ureters
  • Kidney impairment caused by bladder outlet obstruction
  • A very high or increasing residual urine volume
  • Persistent bothersome symptoms despite adequate medication
  • Intolerable medication side effects
  • A preference for a procedural solution rather than lifelong tablets
  • Poor urinary flow with objective evidence of significant obstruction

Earlier surgery may also be appropriate when obstruction is beginning to damage bladder function. Waiting until the bladder has become severely stretched or weak can reduce the improvement achievable after surgery.

When is Duodart unlikely to prevent surgery?

Surgery may still be needed when:

  • The prostate obstruction is mechanically severe
  • A large middle lobe acts like a ball valve at the bladder outlet
  • Urinary retention has already occurred repeatedly
  • Bladder stones or recurrent infections are present
  • Residual urine continues to increase
  • Kidney function or upper urinary tract drainage is affected
  • Symptoms remain troublesome after an adequate trial
  • The bladder has become poorly contractile
  • Side effects make long-term treatment unacceptable

Duodart can reduce future risk; it cannot reliably reverse every established complication of obstruction.

What surgical options are available?

The appropriate procedure depends on prostate size, prostate shape, bleeding risk, bladder function, general health and the importance of preserving ejaculation.

Options may include:

  • Transurethral resection of the prostate: TURP
  • GreenLight laser prostate vaporisation: TUVP
  • Holmium laser enucleation: HoLEP
  • Rezūm water-vapour therapy
  • UroLift
  • Temporary implantable nitinol device: iTind
  • Robotic or open simple prostatectomy for very large glands
  • Other enucleation or minimally invasive techniques

Some minimally invasive treatments are best suited to selected prostate sizes and shapes. Not every option provides the same durability, improvement in urinary flow or preservation of ejaculation.

The bottom line

Duodart combines the relatively quick muscle-relaxing effect of tamsulosin with the slower prostate-shrinking and progression-reducing effect of dutasteride.

It is most useful for men with moderate-to-severe urinary symptoms, a genuinely enlarged prostate and a meaningful risk of future urinary retention or surgery.

Sexual and ejaculatory side effects, dizziness, breast changes and possible mood effects should be discussed before treatment. Duodart also lowers PSA, so ongoing prostate cancer surveillance must be interpreted differently.

The term “post-finasteride syndrome” remains scientifically debated. Duodart does not contain finasteride, but dutasteride acts on the same hormonal pathway, and persistent symptoms reported by a patient deserve careful assessment.

Medication should not be continued indefinitely when symptoms remain severe, complications develop or bladder and kidney function are threatened. In those circumstances, timely prostate surgery may be safer and more effective than simply adding another tablet.

This article provides general information and does not replace personalised medical advice. Patients should not start, stop or alter Duodart without consulting their treating doctor.

So, if you are having difficulty with your lower urinary tract symptoms and you wish to remain conservative in your management and not to fussed about your erectile function and libido, come see your local Brisbane urologist, dr Jo Schoeman, to discuss further options

References and further reading

UroLift for Benign Prostatic Enlargement: A Minimally Invasive Treatment That Preserves Ejaculation

/0 Comments/in , /by

Benign prostatic hyperplasia, or BPH, is a non-cancerous enlargement of the prostate. As the prostate enlarges, its lateral lobes may compress the urethra and obstruct the flow of urine from the bladder.

Common lower urinary tract symptoms include:

  • A weak or interrupted urinary stream
  • Difficulty starting urination
  • Straining to pass urine
  • Urinary frequency and urgency
  • Getting up repeatedly at night
  • Dribbling after urination
  • A feeling that the bladder has not emptied properly

Medication is usually the first treatment offered to men with troublesome symptoms. However, tablets may provide insufficient relief or cause dizziness, tiredness, reduced libido, erectile problems or altered ejaculation.

The UroLift procedure, also called a prostatic urethral lift or PUL, is a minimally invasive surgical therapy, or MIST, that may provide an alternative to long-term medication and conventional prostate surgery.

What is a MIST procedure?

Minimally invasive surgical therapies are designed to improve urinary symptoms with less tissue damage, less bleeding and a shorter recovery than conventional procedures such as TURP or prostate laser surgery.

Different MIST procedures work in different ways. Some use steam or other forms of energy to destroy prostate tissue. Some temporarily remodel the urinary passage. UroLift mechanically moves the obstructing prostate tissue away from the urethra using small permanent implants.

Its principal attractions are:

  • No cutting or removal of prostate tissue
  • No heat, laser or steam
  • Rapid improvement in many patients
  • Usually brief catheterisation, if any
  • Short recovery
  • A low reported risk of new erectile or ejaculatory dysfunction

The trade-off is that symptom improvement is generally more modest than after a tissue-removing operation, permanent implants remain within the prostate, and some patients will eventually require further treatment.

How does UroLift work?

The UroLift system uses small implants to hold the enlarged lateral lobes of the prostate away from the urethra.

Each implant consists of:

  • A small capsular tab placed on the outside of the prostate
  • A stainless-steel urethral end-piece
  • A permanent suture connecting the two components

The implant compresses and retracts the obstructing prostate tissue, widening the urinary channel without cutting, burning or removing tissue.

Most patients require several implants. The exact number depends on the length, size and shape of the prostate and the degree of obstruction. These implants remain permanently in position.

Who may benefit from UroLift?

UroLift may be considered for men who:

  • Have moderate or severe urinary symptoms caused by BPH
  • Have obtained inadequate relief from medication
  • Cannot tolerate the side effects of BPH medication
  • Prefer not to take daily medication indefinitely
  • Want a less invasive alternative to TURP or laser surgery
  • Place a high priority on preserving forward ejaculation
  • Want a relatively rapid return to normal activities
  • Have prostate anatomy suitable for a prostatic urethral lift
  • Understand the possibility of future retreatment

It is particularly attractive for sexually active men who wish to improve their urinary symptoms while minimising the risk of dry or retrograde ejaculation.

What prostate size is suitable?

Clinical guidelines and manufacturer labelling are not identical.

Current European Association of Urology guidance recommends offering prostatic urethral lift to men interested in preserving ejaculation who have prostates smaller than 70 mL and no obstructing middle lobe.

American Urological Association guidance supports the procedure for selected men with prostates approximately 30–80 mL and without an obstructing middle lobe.

Manufacturer and regulatory indications may extend to prostates as large as 100 mL and may include selected median-lobe anatomy in some jurisdictions. However, treatment outside the populations best supported by clinical guidelines requires careful patient selection and counselling.

Prostate volume alone does not determine suitability. The shape of the prostate, length of the prostatic urethra, bladder-neck anatomy, degree of obstruction and strength of the bladder muscle must also be considered.

What about an obstructing median lobe?

The median lobe is prostate tissue that projects upwards towards the bladder and may act like a ball valve over the bladder outlet.

UroLift can be used to treat selected obstructing median lobes, and the MedLift study reported encouraging outcomes. Nevertheless, major guideline recommendations remain more conservative because the strongest long-term randomised evidence relates mainly to lateral-lobe obstruction.

A large, mobile or unusually shaped median lobe may be better treated with TURP, laser surgery, Rezūm, Aquablation or another procedure capable of removing or reducing the obstructing tissue.

This is an important anatomical caveat to discuss before choosing UroLift.

Assessment before treatment

Not every urinary symptom is caused by BPH. Infection, urethral stricture, bladder weakness, overactive bladder, neurological disease, medication and prostate or bladder cancer may produce similar symptoms.

Assessment may include:

  • Medical history and examination
  • International Prostate Symptom Score
  • Urine testing
  • PSA testing when appropriate
  • Urinary-flow measurement
  • Ultrasound measurement of residual urine
  • Prostate imaging or ultrasound
  • Flexible cystoscopy
  • Urodynamic testing in selected patients

Cystoscopy may be particularly useful because it allows the urologist to assess the lateral lobes, bladder neck, median lobe and length of the obstructing prostate.

Any urinary infection should be treated before the procedure.

Patients taking aspirin, warfarin, clopidogrel, apixaban, rivaroxaban or other blood-thinning medication require an individual plan. Do not stop blood-thinning medication without instructions from your prescribing doctor and urologist.

How is the UroLift procedure performed?

UroLift is usually performed as a day procedure under local anaesthetic with sedation or a short general anaesthetic.

A cystoscope and specialised delivery device are passed through the urethra. No external incision is required.

The urologist:

  1. Examines the urethra, prostate and bladder.
  2. Positions the delivery device within the prostatic urethra.
  3. Moves the obstructing prostate tissue away from the urinary channel.
  4. Deploys an implant to hold the tissue in its new position.
  5. Repeats the process at selected points until an adequate channel has been created.
  6. Inspects the bladder outlet and controls any bleeding.

The procedure commonly takes less than an hour, although this varies with prostate anatomy and the number of implants required.

Because no prostate tissue is removed, there is usually no specimen for laboratory examination.

Will I need a catheter?

Many men can pass urine after the procedure and go home without a catheter. A catheter may nevertheless be required if there is:

  • Significant prostate swelling
  • Inability to pass urine
  • Pre-existing urinary retention
  • A weak bladder muscle
  • Bleeding or clot formation
  • A high residual urine volume

When required, the catheter is usually temporary. Patients with chronic retention or poor bladder function have a greater risk of failing an early trial without a catheter.

What should I expect after UroLift?

Temporary urinary irritation is common during the first few days.

You may experience:

  • Burning or stinging when passing urine
  • Urinary urgency and frequency
  • Pelvic, perineal or penile discomfort
  • Light blood in the urine
  • Bladder spasms
  • A temporarily weaker or more irregular stream
  • Increased night-time urination
  • A feeling of incomplete emptying

These symptoms generally improve over several days, although urinary irritation may occasionally persist for a few weeks.

Some men notice an improved stream soon after treatment. For others, the benefit develops over the following two to six weeks as swelling and irritation settle.

Managing pain and urinary discomfort

Discomfort after UroLift is usually mild to moderate.

Management may include:

Paracetamol

Paracetamol is commonly sufficient for mild discomfort. Take it according to the instructions provided by your doctor or the directions on the packet.

Avoid accidentally taking additional paracetamol contained in cold, influenza or combination pain medicines.

Anti-inflammatory medication

Ibuprofen or another anti-inflammatory medicine may help when medically appropriate. These medicines may not be suitable for patients with kidney impairment, stomach ulcers, certain heart conditions, bleeding disorders, anti-inflammatory-sensitive asthma or anticoagulant medication.

Check with your doctor or pharmacist before taking an anti-inflammatory medicine.

Medication for urinary symptoms

An alpha blocker may be continued temporarily to assist urine flow while swelling settles. Medication for bladder spasm or urinary burning may occasionally be prescribed.

Practical measures

It may help to:

  • Maintain normal hydration without forcing excessive fluids
  • Limit coffee, tea, alcohol, fizzy drinks and energy drinks
  • Avoid constipation
  • Avoid heavy lifting and vigorous exercise for several days
  • Take pain relief before discomfort becomes severe

Severe or worsening pain should be reported rather than simply tolerated.

Possible complications

Most side effects are mild and temporary, but complications can occur.

Common temporary effects

These include:

  • Pain or burning during urination
  • Blood in the urine
  • Urinary urgency
  • Increased frequency
  • Pelvic discomfort
  • Temporary urinary leakage associated with urgency

Urinary retention

Some men cannot pass urine after the procedure and require temporary catheterisation. The risk may be greater in patients with high residual urine volumes, chronic retention, severe obstruction or a weak bladder muscle.

Urinary tract infection

Infection may cause worsening burning, cloudy or offensive urine, fever, chills or feeling generally unwell. Antibiotics may be required.

Bleeding

Light haematuria is common. Significant bleeding, clot retention or the need for further intervention is uncommon but possible.

Implant-related problems

Potential implant complications include:

  • Incorrect placement
  • Implant exposure within the bladder
  • Encrustation or stone formation
  • Migration or loosening
  • Persistent pelvic discomfort
  • The need to remove an implant
  • Difficulty or irritation during later prostate surgery

Implants placed too close to or within the bladder are more likely to develop encrustation and may require endoscopic removal.

Persistent symptoms

UroLift treats obstruction but does not correct every cause of lower urinary tract symptoms. Urgency, frequency and nocturia may persist when they are caused by bladder overactivity, excessive night-time urine production, sleep apnoea, fluid intake, diabetes or other medical conditions.

Need for further treatment

Some patients obtain insufficient relief or develop recurrent symptoms as the prostate continues to enlarge. Further treatment may involve medication, additional implants, removal of exposed implants or another procedure such as TURP, GreenLight laser, HoLEP, Rezūm or Aquablation.

When should I seek urgent help?

Contact your urologist or attend an emergency department if you:

  • Cannot pass urine
  • Develop fever, shaking or chills
  • Feel generally unwell or confused
  • Pass large blood clots
  • Have heavy or persistent bright-red bleeding
  • Develop severe or increasing pelvic pain
  • Cannot keep fluids down
  • Experience pain that is not controlled by the recommended treatment

Does UroLift affect erections or ejaculation?

Preserving sexual function is one of the main reasons patients choose UroLift.

The pivotal L.I.F.T. study reported no new sustained erectile or ejaculatory dysfunction during five years of follow-up. Because the bladder neck, prostate tissue and ejaculatory pathways are not routinely cut or heated, the risk of retrograde ejaculation is substantially lower than with conventional TURP and many tissue-removing procedures.

However, no treatment can guarantee unchanged erections, sensation, orgasm or ejaculation in every patient.

Men who already have erectile or ejaculatory difficulties should not assume that UroLift will correct those problems. It is primarily a treatment for urinary obstruction.

How effective is UroLift?

Clinical studies show meaningful average improvement in:

  • Urinary symptom scores
  • Quality of life
  • Peak urinary-flow rate
  • The patient’s perception of urinary function

Symptoms may improve quickly because the urethra is mechanically opened during the procedure.

However, the average improvement in urinary flow and symptoms is generally less than that achieved with TURP or prostate enucleation. UroLift is therefore best understood as a compromise: less invasive treatment and better preservation of ejaculation in exchange for more modest de-obstruction and a greater chance of later retreatment.

How long does UroLift last?

The implants are permanent, but the symptom relief is not necessarily lifelong.

The pivotal L.I.F.T. study demonstrated sustained average improvements for five years. The reported surgical retreatment rate was approximately 13.6% over five years, or roughly 2–3% per year.

Retreatment estimates vary among studies and real-world populations. The need for further treatment may be influenced by:

  • Prostate size and anatomy
  • Median-lobe obstruction
  • Implant position
  • Severity of the original obstruction
  • Bladder function
  • Continued prostate growth
  • The definition of retreatment used in a study

Patients should distinguish between an implant remaining in position and the treatment continuing to control symptoms. A permanent implant does not guarantee permanent symptom relief.

MRI considerations

UroLift implants are classified as MR Conditional, meaning MRI can generally be performed under specified scanner conditions. Patients should tell the radiology service that they have UroLift implants and provide the implant information card whenever possible.

The metallic components can create image artefact, particularly during prostate MRI. This may obscure portions of the prostate and reduce the diagnostic quality of an MRI used to investigate suspected prostate cancer.

This caveat is particularly relevant for:

  • Younger men with a long future need for prostate surveillance
  • Patients with an elevated or rising PSA
  • Men already undergoing prostate cancer monitoring
  • Patients likely to require prostate MRI or targeted biopsy

Appropriate prostate cancer assessment should be completed before UroLift when clinically indicated.

Can prostate surgery still be performed later?

Yes. TURP, laser surgery, HoLEP and other BPH procedures can be performed after UroLift.

However, the surgeon must account for the permanent implants. Clips may be encountered during resection or enucleation, may affect instruments or laser fibres, and may require removal. Some surgeons therefore consider later surgery technically more complex than treatment of an implant-free prostate.

UroLift does not close the door to future treatment, but it does leave permanent material that the future surgeon must manage.

Who should not undergo UroLift?

Manufacturer contraindications include:

  • Active urinary tract infection
  • Current visible or gross haematuria
  • Urinary incontinence caused by an incompetent urinary sphincter
  • A urethral condition that prevents safe insertion of the delivery device
  • A prostate larger than the maximum permitted by the applicable product labelling

UroLift may also be unsuitable or less predictable in men with:

  • Severe chronic urinary retention
  • A poorly contracting bladder
  • Very high residual urine volumes
  • Urethral stricture disease
  • Bladder stones
  • Recurrent urinary infections
  • Significant ongoing bleeding
  • A very high bladder neck
  • A large or unfavourably shaped median lobe
  • A very large prostate
  • Suspected or untreated prostate cancer
  • Symptoms primarily caused by overactive bladder rather than obstruction
  • A need for maximal and durable removal of obstructing tissue

Advantages of UroLift

Potential advantages include:

  • Minimally invasive day procedure
  • No prostate tissue removed
  • No laser, heat or steam
  • Rapid relief in many patients
  • Short recovery
  • Catheter often avoided
  • Low reported risk of new erectile dysfunction
  • Low reported risk of dry or retrograde ejaculation
  • Future BPH treatments remain possible

Limitations and important caveats

Patients should understand that:

  • Several permanent implants remain inside the prostate
  • Symptom and flow improvements are usually less than after TURP or enucleation
  • Retreatment is more common than after tissue-removing surgery
  • Not all median lobes are suitable
  • UroLift does not prevent continued prostate growth
  • Urgency and nocturia may persist if they have a bladder or medical cause
  • The implants may reduce the quality of future prostate MRI
  • Later prostate surgery remains possible but may be technically more complicated
  • Prostate cancer should be appropriately assessed before treatment
  • UroLift does not provide prostate tissue for laboratory examination

Is UroLift the right option for me?

UroLift can be an excellent option for a carefully selected man who wants meaningful improvement in urinary symptoms, a rapid recovery and a low risk of ejaculatory dysfunction.

It may be less suitable for someone with severe obstruction, chronic retention, weak bladder function, unfavourable median-lobe anatomy or a need for the most powerful and durable improvement possible.

The decision should take account of:

  • Prostate size and shape
  • Presence of a median lobe
  • Severity of symptoms and obstruction
  • Bladder strength and residual urine
  • PSA and prostate cancer risk
  • Previous treatment
  • General health and medication
  • Importance of preserving ejaculation
  • Acceptance of permanent implants
  • Willingness to undergo future retreatment

A urological assessment allows UroLift to be compared fairly with medication, iTind, Rezūm, Aquablation, TURP, GreenLight laser, HoLEP and other appropriate options.

This information is intended for general education and does not replace individual medical advice. Treatment suitability, availability and costs vary. Always follow the instructions provided by your treating urologist.

References

  1. European Association of Urology: Management of non-neurogenic male lower urinary tract symptoms.
  2. American Urological Association: BPH clinical guideline.
  3. Roehrborn CG, et al. Five-year results of the prospective randomised controlled prostatic urethral L.I.F.T. study. Canadian Journal of Urology. 2017;24:8802–8813.
  4. Rukstalis D, et al. Prostatic urethral lift for the treatment of an obstructive median lobe: 12-month results of the MedLift study. Prostate Cancer and Prostatic Diseases. 2019;22:411–419.
  5. UroLift manufacturer safety information.
  6. Benidir T, et al. Impact of the UroLift device on prostate magnetic resonance image quality. Journal of Urology. 2023.

If you are troubled by lower urinary tract symptoms but are not yet ready to farewell your forward ejaculation, come and see your Brisbane urologist, Dr Jo, Uro-Jo, to discuss whether UroLift may be an appropriate option for your BPH.

iTind for Benign Prostatic Enlargement: Temporary Treatment Without a Permanent Implant

/0 Comments/in , /by

Benign prostatic hyperplasia—or BPH—is a non-cancerous enlargement of the prostate. As the prostate grows, it may compress the urethra and interfere with emptying the bladder.

Typical symptoms include:

  • A weak or interrupted urinary stream
  • Difficulty starting urination
  • Straining to pass urine
  • Urinary frequency or urgency
  • Getting up repeatedly at night
  • Dribbling after urination
  • A feeling that the bladder has not emptied completely

Medication is often the first treatment. However, tablets do not help every patient and may cause dizziness, tiredness, reduced ejaculation, erectile difficulties or reduced libido. The iTind procedure offers selected men a minimally invasive alternative to long-term medication or conventional prostate surgery.

What is iTind?

The iTind is a small temporary device made from nitinol, a flexible nickel–titanium alloy with “shape memory.”

It is sometimes called a temporary prostatic stent, although it differs from a traditional stent because it is not intended to remain permanently within the prostate. The device is left in place for only five to seven days and is then removed completely.

While in position, three expanding struts apply controlled pressure to specific areas of the prostate and bladder neck. This remodels the prostatic urethra and creates channels through which urine can flow more easily.

The procedure does not:

  • Permanently implant metal within the prostate
  • Remove prostate tissue
  • Use laser, heat or steam
  • Prevent future prostate treatments if symptoms return

Who may benefit from iTind?

iTind may be considered for men who have bothersome urinary symptoms caused by BPH and who:

  • Have obtained insufficient benefit from medication
  • Have developed side effects from BPH tablets
  • Prefer not to take daily medication indefinitely
  • Want a less invasive alternative to TURP or laser surgery
  • Wish to minimise the risk of ejaculatory or erectile side effects
  • Prefer not to have a permanent prostatic implant
  • Have prostate size and anatomy suitable for the device

The procedure is generally best suited to men with moderate-to-severe symptoms and a prostate measuring approximately 25–75 mL, without a significantly obstructing median lobe.

These measurements are a guide rather than a guarantee of suitability. The shape of the prostate, severity of obstruction and function of the bladder are as important as prostate size.

Assessment before treatment

Urinary symptoms are not always caused by an enlarged prostate. Similar problems can result from infection, urethral narrowing, bladder weakness, an overactive bladder, neurological disease, medication or, less commonly, cancer.

Assessment may therefore include:

  • Medical history and examination
  • International Prostate Symptom Score
  • Urine testing
  • PSA testing when appropriate
  • Urinary-flow measurement
  • Ultrasound measurement of residual urine
  • Prostate ultrasound or other imaging
  • Flexible cystoscopy
  • Urodynamic testing in selected patients

Any urinary infection should be treated before the procedure.

Patients taking aspirin, warfarin, clopidogrel, apixaban, rivaroxaban or other blood-thinning medication require an individual management plan. Do not stop blood thinners without instructions from your prescribing doctor and urologist.

How is the iTind procedure performed?

Insertion

The folded iTind device is passed through the urethra using a small cystoscope. It is positioned in the prostatic urethra immediately below the bladder neck and then released.

The procedure is usually performed as day surgery. Depending on the patient and treatment setting, local anaesthetic, intravenous sedation or a short general anaesthetic may be used.

A soft retrieval string remains attached to the device and passes out through the urethra. It is usually secured to the penis until the device is removed.

Most patients can return home on the same day without a urinary catheter. Occasionally, temporary catheterisation is necessary if the patient is unable to pass urine.

The treatment period

The device remains inside the prostate for five to seven days. Its struts gradually apply pressure to the prostate and bladder neck, creating three longitudinal channels within the urinary passage.

Patients remain at home during this treatment period.

Removal

The device must be removed after five to seven days. It is collapsed into a soft catheter and withdrawn in one piece, usually during a brief outpatient visit.

Local anaesthetic gel is often sufficient, although additional pain relief or sedation may be offered when appropriate. No metal or permanent implant remains inside the prostate after removal.

What should I expect while the device is in place?

The five-to-seven-day treatment period is generally the most uncomfortable part of the process. Common temporary symptoms include:

  • Pelvic or perineal pressure
  • Burning or stinging when passing urine
  • Urinary urgency and frequency
  • Discomfort at the tip of the penis
  • Bladder spasms
  • Light bleeding in the urine
  • Interrupted sleep
  • Awareness of the retrieval string
  • A temporarily weak or irregular urinary stream

These symptoms are usually mild to moderate and commonly improve soon after the device is removed.

Patients should generally avoid heavy lifting, vigorous exercise, cycling and sexual activity while the device and retrieval string are in place. Follow the particular instructions provided by your urologist.

The retrieval string should not be pulled, cut, repositioned or removed by the patient.

How can pain and discomfort be managed?

Pain varies considerably between patients. Some men experience only mild pressure, while others find urinary urgency, bladder spasm or discomfort from the retrieval string more troublesome.

A pain-management plan may include the following measures.

Paracetamol

Paracetamol is usually the first choice for mild-to-moderate discomfort. Take it according to your doctor’s instructions or the directions on the packet.

Check cold, influenza and combination pain medicines carefully, as these may also contain paracetamol. Do not exceed the recommended daily dose.

Patients with significant liver disease or heavy alcohol consumption should discuss paracetamol use with their doctor.

Anti-inflammatory medication

An anti-inflammatory medicine such as ibuprofen may help reduce pain and inflammation when medically appropriate.

These medications may not be suitable for patients with:

  • Kidney impairment
  • Stomach ulcers or gastrointestinal bleeding
  • Heart failure or certain cardiovascular conditions
  • Asthma triggered by anti-inflammatory medication
  • Bleeding disorders
  • Anticoagulant or antiplatelet treatment

Check with your urologist, general practitioner or pharmacist before taking an anti-inflammatory medication.

Medication for bladder irritation

An alpha blocker may occasionally be continued or prescribed temporarily to help urine flow. A bladder-calming medication may be considered if urgency or bladder spasms are particularly troublesome.

These medicines are not necessary for every patient and have their own potential side effects.

Practical measures

It may also help to:

  • Maintain normal hydration without forcing excessive fluids
  • Reduce coffee, tea, cola drinks, alcohol and energy drinks
  • Avoid constipation
  • Wear loose, supportive underwear
  • Avoid heavy lifting and strenuous exercise
  • Take pain relief early rather than waiting until discomfort becomes severe

Strong opioid medication is not usually required. It may worsen constipation and, in susceptible patients, contribute to difficulty emptying the bladder.

Severe or increasing pain is not considered something that should simply be tolerated. Contact the treating practice if the discomfort is not controlled by the recommended measures.

What happens after removal?

Burning, urinary urgency and light bleeding may continue briefly after the device is removed, but these symptoms should progressively improve.

Some patients notice an improvement in their stream soon after removal. For others, improvement develops more gradually over several weeks as irritation settles and the remodelled urinary channels stabilise.

Many patients return to normal daily activities within a few days. Your urologist will advise when you may resume strenuous exercise and sexual activity.

Follow-up may include:

  • Review of urinary symptoms
  • Repeat symptom scoring
  • A urinary-flow test
  • Measurement of residual urine
  • Discussion about continuing or stopping BPH medication

Do not stop established prostate medication unless advised to do so.

Side effects and possible complications

Most side effects are temporary and occur while the device is in place. Reported problems include:

  • Burning during urination
  • Urinary frequency and urgency
  • Pelvic discomfort or pain
  • Blood in the urine
  • Temporary difficulty passing urine
  • Urinary tract infection
  • Bladder spasm
  • Movement or incorrect positioning of the device
  • Temporary catheterisation
  • Failure to obtain sufficient symptom relief

Published studies report different complication rates, but most events have been mild and self-limiting. Temporary haematuria, dysuria, urgency and pelvic discomfort are the most frequently reported problems.

Acute urinary retention, urinary infection or significant bleeding are less common but important complications.

When should I seek urgent medical attention?

Contact your urologist or attend an emergency department if you:

  • Cannot pass urine
  • Develop fever, shaking or chills
  • Feel generally unwell or confused
  • Develop severe or increasing pelvic pain
  • Pass large blood clots
  • Have heavy or persistent bright-red bleeding
  • Cannot keep fluids down
  • Notice that the retrieval string or device has moved
  • Develop pain that is not controlled by the agreed treatment plan

Does iTind affect erections or ejaculation?

One of the principal attractions of iTind is its favourable sexual side-effect profile.

Clinical studies have reported preservation of erectile and ejaculatory function in most treated patients. This contrasts with tissue-removing prostate procedures, which may carry a significant risk of retrograde or absent ejaculation.

Nevertheless, no treatment can guarantee that sexual or ejaculatory function will remain unchanged in every patient.

How effective is iTind?

Studies have demonstrated average improvements in:

  • Urinary symptom scores
  • Quality of life
  • Peak urinary-flow rate
  • The patient’s perception of urinary function

The improvement may be less dramatic than that achieved with a tissue-removing operation such as TURP or laser enucleation. The advantage is that iTind is less invasive, usually requires little recovery time and has a low reported risk of sexual side effects.

It is therefore best viewed as a balance between symptom improvement and treatment invasiveness.

How long does the benefit last?

Although the implant remains in place for only five to seven days, the channels produced within the prostate may remain open for several years.

Prospective studies have demonstrated sustained benefit for more than four years in some appropriately selected patients. This does not mean that iTind is guaranteed to last for four years—or that it will provide lifelong relief.

BPH may continue to progress as a man ages. Some patients will eventually need to restart medication or undergo another procedure. Longer-term evidence for iTind remains more limited than that available for established procedures such as TURP or laser enucleation.

Because nothing is left permanently inside the prostate, iTind does not generally prevent later treatment. Options may include medication, another minimally invasive procedure, TURP, GreenLight laser treatment, HoLEP or another form of prostate surgery.

Who should not undergo iTind?

Contraindications described in the manufacturer’s information include:

  • Active urinary tract infection
  • Acute prostatitis
  • Known prostate cancer
  • Known bladder cancer
  • An artificial urinary sphincter or another implant within the urethra
  • Bladder atonia or a non-contractile bladder
  • Neurogenic bladder dysfunction
  • Urinary obstruction caused by a urethral stricture or something other than BPH

The procedure may also be unsuitable or less predictable in men with:

  • A significantly obstructing median prostatic lobe
  • A prostate outside the best-studied size range
  • Severe chronic urinary retention
  • Very high residual urine volumes
  • Recurrent urinary infections
  • Bladder stones
  • Significant ongoing haematuria
  • Advanced bladder weakness
  • A need for rapid and substantial removal of obstructing tissue
  • Anatomy that prevents safe cystoscopic access

Previous prostate surgery, urethral surgery, nickel sensitivity and blood-thinning medication require individual consideration.

Patients with obstruction causing kidney impairment, repeated retention, recurrent infections, bladder stones or significant bleeding may receive more reliable relief from a definitive tissue-removing procedure.

Advantages of iTind

Potential advantages include:

  • Minimally invasive day procedure
  • No cutting, laser, steam or thermal energy
  • No permanent implant
  • Usually no postoperative catheter
  • Rapid return to ordinary activities
  • Low reported risk of new erectile dysfunction
  • Low reported risk of ejaculatory dysfunction
  • Does not usually compromise future BPH treatment

Limitations of iTind

Potential limitations include:

  • Discomfort during the treatment week
  • A retrieval string for five to seven days
  • A second procedure to remove the device
  • Not suitable for every prostate shape or size
  • Less improvement than some tissue-removing procedures
  • Possibility of persistent or recurrent symptoms
  • Potential need for future medication or surgery
  • Less very-long-term evidence than TURP or laser enucleation

Is iTind the right treatment for me?

iTind is not simply a smaller version of TURP. It offers a different compromise: a less invasive procedure with no permanent implant and a favourable sexual side-effect profile, but generally more modest improvement and less long-term evidence than tissue-removing surgery.

The best treatment depends on:

  • The severity of your symptoms
  • The size and shape of your prostate
  • The amount of urinary obstruction
  • Bladder strength and residual urine
  • Previous treatment
  • General health and medication
  • The importance of preserving ejaculation
  • Your willingness to accept possible future retreatment

A urological assessment is essential to confirm that BPH is responsible for the symptoms and to compare iTind fairly with medication, Rezūm, UroLift, TURP, GreenLight laser, HoLEP and other appropriate treatments.

This information is intended for general education and does not replace individual medical advice. Treatment suitability, availability and costs vary. Always follow the instructions provided by your treating urologist.

References

  1. Sandhu JS, et al. Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: AUA Guideline Amendment 2023. Journal of Urology. 2024.
  2. Chughtai B, et al. The iTind Temporarily Implanted Nitinol Device for the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Multicentre, Randomised, Controlled Trial. Urology. 2021;153:270–276.
  3. Kadner G, et al. Second generation of temporary implantable nitinol device in men with lower urinary tract symptoms: two-year results of the MT-02 study. World Journal of Urology. 2020;38:3235–3244.
  4. Amparore D, et al. Three-year results following treatment with the second-generation temporary implantable nitinol device. Prostate Cancer and Prostatic Diseases. 2021;24:349–357.
  5. Amparore D, et al. Temporary implantable nitinol device for BPH-related lower urinary tract symptoms: over 48-month results. Minerva Urology and Nephrology. 2023;75:743–751.
  6. NICE: iTind for lower urinary tract symptoms caused by BPH.
  7. Olympus: iTind clinical and procedural information.

So, if you are experiencing LUTS, lower urinary tract symptoms, and you are not yet ready to farewell your prograde ejaculation function, come see your Brisbane urologist, Dr Jo, Uro-Jo and discuss this option for your BPH.

What to Expect on Your First Visit to Dr. Jo Schoeman

/in /by

When you schedule your first visit with Dr. Jo Schoeman, a premier urologist in Brisbane, you’re taking an essential step toward addressing your urological health. Understanding what to expect during this initial consultation can help ease any anxieties and ensure you come fully prepared. Here’s a comprehensive guide to help you navigate your first visit.

 

Preparation for Your Appointment

Before heading to your appointment, gather all relevant radiology and pathology results ordered by your referring physician. These documents are crucial for Dr. Jo to review your medical history thoroughly and provide an accurate diagnosis.

Additionally, ensure you attend with a semi-full bladder, as an ultrasound may be part of your evaluation. This preparation helps facilitate a more comprehensive examination.

 

Thorough Physical Investigation

Your first visit will involve a thorough physical examination tailored to your specific needs. For male patients, this includes an internal investigation of the prostate. Female patients experiencing incontinence or pelvic organ prolapse will also undergo an internal investigation. These assessments are essential for identifying any underlying issues and forming a basis for your treatment plan.

 

Discussing Your Diagnosis

Dr. Jo will discuss your differential diagnosis with you, explaining the potential causes of your symptoms. This open dialogue ensures you are fully informed about your condition and the steps needed for further evaluation.

 

Additional Testing

In some cases, Dr. Jo may recommend additional tests to gain a deeper understanding of your condition. These tests are vital for creating a detailed and accurate treatment plan.

 

Conservative Management

Dr. Jo prioritises conservative management as the first line of therapy. This approach includes lifestyle changes, medications, or other non-invasive treatments to address your condition effectively. Surgery is considered only when absolutely necessary.

 

Surgical Consultation

If surgery is indicated, Dr. Jo will discuss the procedure in detail, covering all possible side effects and complications. You will receive a comprehensive information brochure detailing the discussed points, a copy of your consent form, and an estimate of Dr. Jo’s fees for the procedure. This information is vital for providing fully informed consent.

 

Consent and Follow-Up

Should you proceed with surgery, it’s essential to read the provided brochure and bring it on the day of your surgical appointment. This ensures you are fully informed and comfortable with the proposed surgical procedure.

 

Building a Professional Relationship

Your first visit forms the foundation of your professional relationship with Dr. Jo. Open communication and thorough preparation ensure you receive the best possible care tailored to your specific needs.

 

Visiting Dr. Jo Schoeman, a leading urologist in Brisbane, for the first time might feel daunting, but knowing what to expect can help put you at ease. From thorough examinations to detailed discussions about your diagnosis and treatment options, Dr. Jo is dedicated to providing exceptional care and ensuring you feel informed and supported throughout your journey to better health.

For more information or to schedule your first visit, contact us today. Take the first step towards optimal urological health with Dr. Jo Schoeman.

 

Dr. Jo Schoeman

Phone : (07) 3371 7288

Location :

WESLEY HOSPITAL

Suite 46, Level 4
The Wesley Medical Centre

Wesley Hospital
24 Chasely Street
Auchenflower, 4066

Prostate Health and Urology

/in /by

When it comes to men’s health, one topic that often takes center stage is prostate health. As a vital part of the male reproductive system, the prostate plays a crucial role in urinary function and overall well-being. We sit down with Dr. Jo Scheoman, a renowned urologist based in Brisbane, to discuss the importance of prostate health and its connection to urology.

 

Meet Dr. Jo Scheoman
Dr. Jo Scheoman is a highly respected urologist with years of experience in diagnosing and treating a wide range of urological conditions. Specialising in prostate health, Dr. Scheoman is dedicated to providing compassionate care and innovative treatments to patients in Brisbane and beyond. With a focus on patient education and empowerment, Dr. Scheoman strives to raise awareness about the importance of proactive prostate health management.

 

Understanding Prostate Health:
The prostate is a small gland located below the bladder and in front of the rectum. Its primary function is to produce fluid that nourishes and protects sperm. As men age, the prostate can undergo changes that may affect urinary function and overall health. Common prostate conditions include:

– Benign Prostatic Hyperplasia (BPH): Enlargement of the prostate gland, which can lead to urinary symptoms such as frequent urination, urgency, and incomplete emptying of the bladder.
– Prostatitis: Inflammation or infection of the prostate gland, often causing pain or discomfort in the pelvic area and changes in urinary habits.
– Prostate Cancer: The most common cancer in men, prostate cancer occurs when abnormal cells develop in the prostate gland. Early detection and treatment are critical for favorable outcomes.

 

The Role of Urology in Prostate Health:
As a specialised field of medicine, urology focuses on the diagnosis and treatment of conditions affecting the urinary tract and male reproductive system, including the prostate. Urologists like Dr. Scheoman play a vital role in assessing prostate health, diagnosing conditions, and recommending appropriate treatment options. From routine screenings and diagnostic tests to advanced surgical procedures, urologists are equipped to address a wide range of prostate-related concerns.

urologist brisbane, urology brisbane,

Maintaining Prostate Health:
While certain risk factors for prostate conditions, such as age and family history, are beyond our control, there are steps men can take to promote prostate health and reduce the risk of developing prostate-related issues. These include:

– Healthy Lifestyle: Adopting a balanced diet rich in fruits, vegetables, and lean proteins, along with regular exercise, can support overall health and reduce the risk of obesity, which is linked to prostate issues.
–  Regular Check-ups: Scheduling routine check-ups with a urologist for prostate screenings and evaluations is essential for early detection and intervention.
– Awareness and Education: Staying informed about prostate health and understanding the signs and symptoms of prostate conditions can empower men to take proactive steps towards their well-being.

 

Prostate health is a critical aspect of men’s overall well-being, and proactive management is key to maintaining optimal health and quality of life. With the expertise and guidance of urologists like Dr. Jo Scheoman, men can take control of their prostate health and enjoy a fulfilling, healthy life. Whether it’s preventive screenings, diagnostic evaluations, or personalized treatment plans, urologists play a crucial role in supporting men’s health every step of the way. If you’re in Brisbane and seeking expert urological care, Dr. Jo Scheoman is here to provide compassionate, comprehensive services tailored to your unique needs.

Phone : (07) 3371 7288

Website : https://www.drjoschoeman.com.au/

WESLEY HOSPITAL

Suite 10, Level 9
Evan Thomson Building
24 Chasely Street
Auchenflower, 4066